Now showing items 1-4 of 4
Negative epistasis between the malaria-protective effects of α + - thalassemia and the sickle cell trait
(Nature Genetics, 2005-11)
The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria1. In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural ...
Sickle Cell Trait and the Risk of Plasmodium falciparum Malaria and Other Childhood Diseases
(Journal of Infectious Diseases, 2005-07)
Background—The gene for sickle hemoglobin (HbS) is a prime example of natural selection. It is generally believed that its current prevalence in many tropical populations reflects selection for the carrier form (sickle ...
Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1
Background: Antibodies targeting variant antigens expressed on the surface of Plasmodium falciparum infected erythrocytes have been associated with protection from clinical malaria. The precise target for these antibodies ...
HIV, Malnutrition and Invasive Bacterial Infection among Children with Severe Malaria
(Clinical Infectious Diseases, 2009-08-01)
Abstract Background—HIV infection, malnutrition and invasive bacterial infections (IBI) are reported among children with severe malaria. However, it is unclear whether their co-occurrence with falciparum parasitization ...