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Negative epistasis between the malaria-protective effects of α + - thalassemia and the sickle cell trait
(Nature Genetics, 2005-11)
The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria1. In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural ...
Eff ect of a fall in malaria transmission on morbidity and mortality in Kilifi , Kenya
Summary Background As eff orts to control malaria are expanded across the world, understanding the role of transmission intensity in determining the burden of clinical malaria is crucial to the prediction and measurement ...