Browsing by Author "Eric J Thomas"

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Synthesis of 5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M3) receptors.

Benjamin Bradshaw; Paul Evans; Jane Fletcher; Alan T L Lee; Paul G Mwashimba; Daniel Oehlrich; Eric J Thomas; Robin H Davies; Benjamin C P Allen; Kenneth J Broadley; Amar Hamrouni (PubMed, 2008-06-21)

Two approaches to tetrahydro-[1H]-2-benzazepin-4-ones of interest as potentially selective, muscarinic (M(3)) receptor antagonists have been developed. Base promoted addition of 2-(tert-butoxycarbonylamino)methyl-1,3-dithiane ...