Browsing by Author "Lang, Trudie"
Now showing items 1-3 of 3
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Extended Follow-Up Following a Phase 2b Randomized Trial of the Candidate Malaria Vaccines FP9 ME-TRAP and MVA ME-TRAP among Children in Kenya
Bejon, Philip; Ogada, Edna; Mwangi, Tabitha; Milligan, Pau; Lang, Trudie; Fegan, Greg; Gilbert, Sarah C.; Peshu, Norbert; Marsh, Kevin; Hil, Adrian V. S. (Plos One, 2007)Background. ‘‘FFM ME-TRAP’’ is sequential immunisation with two attenuated poxvirus vectors (FP9 and modified vaccinia virus Ankara) delivering the pre-erythrocytic malaria antigen ME-TRAP. Over nine months follow-up in ... -
The Induction and Persistence of T Cell IFN- γ Responses after Vaccination or Natural Exposure Is Suppressed by Plasmodium falciparum 1
Bejon, Philip; Mwacharo, Jedidah; Kai, Oscar; Todryk, Stephen; Keating, Sheila; Lowe, Brett; Lang, Trudie; Mwangi, Tabitha; Gilbert, Sarah C.; Peshu, Norbert; Marsh, Kevin; Hil, Adrian V. S. (Journal of Immunology, 2007-09-15)Abstract Epidemiological observations suggest that T cell immunity may be suppressed in malaria-endemic areas. In vitro studies, animal models, and limited data in humans link immunosuppression with malaria, malnutrition, ... -
A Phase 2b Randomised Trial of the Candidate Malaria Vaccines FP9 ME-TRAP and MVA ME-TRAP among Children in Kenya
Bejon, Philip; Mwacharo, Jedidah; Kai, Oscar; Tabitha, Mwangi; Milligan, Paul; Todryk, Stephen; Keating, Sheila; Lang, Trudie; Lowe, Brett; Gikonyo, Caroline; Molyneux, Catherine; Fegan, Greg; Gilbert, Sarah C.; Peshu, Norbert; Marsh, Kevin; Hill, Adrian V. S. (PLoS Clinical Trials, 2006)Objective: The objective was to measure the efficacy of the vaccination regimen FFM METRAP in preventing episodes of clinical malaria among children in a malaria endemic area. FFM ME-TRAP is sequential immunisation with ...