Browsing by Author "Macharia, Alex"

Now showing items 1-2 of 2

    • Negative epistasis between the malaria-protective effects of α + - thalassemia and the sickle cell trait 

      Williams, Thomas N; Mwangi, Tabitha; Wambua, Sammy; Peto, Timothy E A; Weatherall, David J; Gupta, Sunetra; Recker, Mario; Penman, Bridget S; Uyoga, Sophie; Macharia, Alex; Mwacharo, Jedidah K; Snow, Robert W; Marsh, Kevin (Nature Genetics, 2005-11)
      The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria1. In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural ...

    • Transmission-Dependent Tolerance to Multiclonal Plasmodium falciparum Infection 

      Färnert, Anna; Williams, Thomas N.; Mwangi, Tabitha W.; Ehlin, Anna; Fegan, Greg; Macharia, Alex; Lowe, Brett S.; Montgomery, Scott M.; Marsh, Kevin (Journal of Infectious Diseases, 2009-10-01)
      Abstract Whether the number of concurrent clones in asymptomatic Plasmodium falciparum infections reflects the degree of host protection was investigated in children living in areas with different levels of transmission ...