Browsing by Author "Macharia, Alex W."

Now showing items 1-2 of 2

The Effect of aþ-Thalassaemia on the Incidence of Malaria and Other Diseases in Children Living on the Coast of Kenya

Wambua, Sammy; Mwangi, Tabitha; Kortok, Moses; Uyoga, Sophie M.; Macharia, Alex W.; Mwacharo, Jedidah K.; Weatherall, David J.; Snow, Robert W.; Marsh, Kevin; Williams, Thomas N. (PLos Medicine, 2006-04-18)

Background The a-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, ...
The Haptoglobin 2-2 Genotype Is Associated with a Reduced Incidence of Plasmodium falciparum Malaria in Children on the Coast of Kenya

Atkinson, Sarah H.; Mwangi, Tabitha; Uyoga, Sophie M.; Ogada, Edna; Macharia, Alex W.; Marsh, Kevin; Prentice, Andrew M.; Williams, Thomas N. (Clinical Infectious Diseases, 2007-03-15)

Background—Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp2 allele is thought to have spread under strong ...