Browsing Department of Biochemistry and Biotechnology by Subject "natural products"

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Utility of the Ammonia-Free Birch Reduction of Electron-Deficient Pyrroles: Total Synthesis of the 20S Proteasome Inhibitor, clasto-Lactacystin β-Lactone

Timothy J. Donohoe Prof.; Herman O. Sintim Dr.; Leena Sisangia Dr.; Karl W. Ace Dr.; Paul M. Guyo Dr.; Andrew Cowley Dr.; John D. Harling Dr (Wiley Online Library, 2005-05-02)

A new synthesis of the 20S proteasome inhibitor clasto-lactacystin β-lactone is described. Our route to this important natural product involves the partial reduction of an electron deficient pyrrole as a key step. By ...