Browsing Department of Biochemistry and Biotechnology by Subject "pyrroles"
Now showing items 1-4 of 4
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The Birchreduction of 3-substituted pyrroles
(ELSELVIER, 1998-05-07)The Birchreduction of electron-deficient 3-substituted pyrroles is described. Use of a reductive alkylation procedure involving sodium metal in liquid ammonia gave good yields of 4-alkyl-2-pyrrolines. The identity of these ... -
The stereoselectiveBirchreduction of pyrroles
(ELSELVIER, 1999-01-15)The Birchreduction has been applied to electron-deficient pyrroles substituted with a chiral auxiliary at the C-2 position. Using either 8-phenylmenthol ortrans-2-(α-cumyl)cyclohexanol (TCC) as auxiliaries, high levels of ... -
Utility of the Ammonia-Free Birch Reduction of Electron-Deficient Pyrroles: Total Synthesis of the 20S Proteasome Inhibitor, clasto-Lactacystin b-Lactone
(Chem. Eur. J., 2005)A new synthesis of the 20S proteasome inhibitor clasto-lactacystin b-lactone is described. Our route to this important natural product involves the partial reduction of an electron deficient pyrrole as a key step. By ... -
Utility of the Ammonia-Free Birch Reduction of Electron-Deficient Pyrroles: Total Synthesis of the 20S Proteasome Inhibitor, clasto-Lactacystin β-Lactone
(Wiley Online Library, 2005-05-02)A new synthesis of the 20S proteasome inhibitor clasto-lactacystin β-lactone is described. Our route to this important natural product involves the partial reduction of an electron deficient pyrrole as a key step. By ...