Browsing Department of Biological Sciences by Author "Kortok, Moses"

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The Effect of aþ-Thalassaemia on the Incidence of Malaria and Other Diseases in Children Living on the Coast of Kenya

Wambua, Sammy; Mwangi, Tabitha; Kortok, Moses; Uyoga, Sophie M.; Macharia, Alex W.; Mwacharo, Jedidah K.; Weatherall, David J.; Snow, Robert W.; Marsh, Kevin; Williams, Thomas N. (PLos Medicine, 2006-04-18)

Background The a-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, ...
Sickle Cell Trait and the Risk of Plasmodium falciparum Malaria and Other Childhood Diseases

Williams, Thomas N; Mwangi, Tabitha; Wambua, Sammy; Alexander, Neal D.; Kortok, Moses; Snow, Robert W.; Marsh, Kevin (Journal of Infectious Diseases, 2005-07)

Background—The gene for sickle hemoglobin (HbS) is a prime example of natural selection. It is generally believed that its current prevalence in many tropical populations reflects selection for the carrier form (sickle ...