Browsing Department of Biological Sciences by Author "Snow, Robert W."

Now showing items 1-3 of 3

    • The Effect of aþ-Thalassaemia on the Incidence of Malaria and Other Diseases in Children Living on the Coast of Kenya 

      Wambua, Sammy; Mwangi, Tabitha; Kortok, Moses; Uyoga, Sophie M.; Macharia, Alex W.; Mwacharo, Jedidah K.; Weatherall, David J.; Snow, Robert W.; Marsh, Kevin; Williams, Thomas N. (PLos Medicine, 2006-04-18)
      Background The a-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, ...

    • Heritability of Malaria in Africa 

      Mackinnon, Margaret J.; Mwangi, Tabitha; Snow, Robert W.; Marsh, Kevin; Williams, Thomas N. (PLoS MEDICINE, 2008-11-08)
      Background While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown. Methods and Findings We have used pedigree-based ...

    • Sickle Cell Trait and the Risk of Plasmodium falciparum Malaria and Other Childhood Diseases 

      Williams, Thomas N; Mwangi, Tabitha; Wambua, Sammy; Alexander, Neal D.; Kortok, Moses; Snow, Robert W.; Marsh, Kevin (Journal of Infectious Diseases, 2005-07)
      Background—The gene for sickle hemoglobin (HbS) is a prime example of natural selection. It is generally believed that its current prevalence in many tropical populations reflects selection for the carrier form (sickle ...