• Login
    View Item 
    •   Repository Home
    • Research Articles
    • Department of Biomedical Sciences
    • View Item
    •   Repository Home
    • Research Articles
    • Department of Biomedical Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    B Cell Memory to 3 Plasmodium falciparum Blood-Stage Antigens in a Malaria-Endemic Area

    Thumbnail
    View/Open
    B Cell Memory to 3 Plasmodium falciparum.pdf (447.5Kb)
    Date
    2005-05
    Author
    Dorfman, Jeffrey R.
    Bejon, Philip
    Ndungu, Francis M.
    Langhorne, Jean
    Kortok, Moses Mosobo
    Lowe, Brett S.
    Mwangi, Tabitha
    Williams, Thomas N.
    Marsh, Kevin
    Metadata
    Show full item record
    Abstract
    To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigenspecific memory B cells from donors in an area where malaria is endemic.We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens: the Cterminal portion of merozoite surface protein 1 (MSP119), apical membrane antigen 1 (AMA1), and the cysteinerich interdomain region 1a (CIDR1a) of a protein from the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. These data are the first to be generated on memory B cells in children who are in the process of acquiring antimalarial immunity, and they reveal defects in B cell memory to P. falciparum antigens. Compared with the results for tetanus toxoid, more donors who were positive for antibody to AMA1 and CIDR1a were negative for memory B cells. These data imply that some exposures to malaria do not result in the establishment of stable populations of circulating antigen-specific memory B cells, suggesting possible mechanisms for the short-lived nature of many anti-malarial antibody responses.
    URI
    http://hdl.handle.net/123456789/593
    Collections
    • Department of Biomedical Sciences

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of PUSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV