Browsing Department of Biomedical Sciences by Title
Now showing items 19-26 of 26
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Malaria and helminth interactions in humans: an epidemiological viewpoint
(Ann Trop Med Parasitol., 2006-10)Abstract Helminths are among the most common chronic infections in the tropics and Plasmodium infections the most deadly. These two groups of parasites have similar geographical distribution and co-infection is commonplace. ... -
Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3
(Parasite Immunology, 2007)Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune ... -
Negative epistasis between the malaria-protective effects of α + - thalassemia and the sickle cell trait
(Nature Genetics, 2005-11)The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria1. In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural ... -
Peripheral blood dendritic cells in children with acute Plasmodium falciparum Malaria
(Blood, 2001)The importance of dendritic cells (DCs) for the initiation and regulation of immune responses not only to foreign organisms but also to the self has raised considerable interest in the qualitative and quantitative ... -
A Phase 2b Randomised Trial of the Candidate Malaria Vaccines FP9 ME-TRAP and MVA ME-TRAP among Children in Kenya
(PLoS Clinical Trials, 2006)Objective: The objective was to measure the efficacy of the vaccination regimen FFM METRAP in preventing episodes of clinical malaria among children in a malaria endemic area. FFM ME-TRAP is sequential immunisation with ... -
A Polymorphism of Intercellular Adhesion Molecule-1 Is Associated with a Reduced Incidence of Nonmalarial Febrile Illness in Kenyan Children
(Clinical Infectious Diseases, 2005-12-15)An intercellular adhesion molecule-1 polymorphism (ICAM-1Kilifi) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared ... -
Protection against Clinical Malaria by Heterologous Immunoglobulin G Antibodies against Malaria- Infected Erythrocyte Variant Surface Antigens Requires Interaction with Asymptomatic Infections
(Journal of Infectious Diseases, 2004)Erythrocytes infected with mature stages of Plasmodium falciparum express variant surface antigens (VSAs) of parasite origin, including P. falciparum erythrocyte membrane protein 1. Anti-VSA antibodies protect against clinical ... -
Relationship Between Exposure, Clinical Malaria, and Age in an Area of Changing Transmission Intensity
(Am J Trop Med Hyg., 2008-08)Abstract The relationship between malaria transmission intensity and clinical disease is important for predicting the outcome of control measures that reduce transmission. Comparisons of hospital data between areas of ...